Di kelas MotoGP, Honda mengantarnya menjadi runner-up klasemen akhir sebanyak tiga kali, pada 2007, 2010 dan 2012.
Bisa jadi, ini salah satu faktor Dani Pedrosa tidak mau pindah ke lain hati, setelah rumor menyebut dirinya akan bergabung ke tim satelit Yamaha tahun depan.
Wah, Dani Pedrosa membuktikan slogan Honda "Satu HATI. One HEART." nih, satu hati bersama Honda.
| Musim | Kelas | Motor | Tim |
| 2001 | 125 cc | Honda RS125 | Televonica MoviStar Junior Team |
| 2002 | 125 cc | Honda RS125 | Televonica MoviStar Junior Team |
| 2003 | 125 cc | Honda RS125 | Televonica MoviStar Junior Team |
| 2004 | 250 cc | Honda RS250R | Televonica MoviStar Honda250cc |
| 2005 | 250 cc | HondaRS250R | Televonica MoviStar Honda250cc |
| 2006 | MotoGP | HondaRC211V | Repsol Honda Team |
| 2007 | MotoGP | HondaRC212V | Repsol Honda Team |
| 2008 | MotoGP | HondaRC212V | Repsol Honda Team |
| 2009 | MotoGP | HondaRC212V | Repsol Honda Team |
| 2010 | MotoGP | HondaRC212V | Repsol Honda Team |
| 2011 | MotoGP | HondaRC212V | Repsol Honda Team |
| 2012 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2013 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2014 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2015 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2016 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2017 | MotoGP | HondaRC213V | Repsol Honda Team |
| 2018 | MotoGP | HondaRC213V | Repsol Honda Team |